Leptin therapy for partial lipodystrophy linked to a PPAR-gamma mutation.

@article{Guettier2008LeptinTF,
  title={Leptin therapy for partial lipodystrophy linked to a PPAR-gamma mutation.},
  author={Jean-Marc Guettier and Jean Y Park and E Cochran and Christine Poitou and Arnaud Basdevant and Muriel Meier and Karine Cl{\'e}ment and Jocelyne Magr{\'e} and Phillip Gorden},
  journal={Clinical endocrinology},
  year={2008},
  volume={68 4},
  pages={
          547-554
        }
}
AIMS/HYPOTHESIS Partial lipodystrophy (PL) is most commonly characterized by loss of subcutaneous fat in the extremities with preservation of truncal fat and is associated with insulin resistance, diabetes and hyperlipidaemia. Recombinant human leptin (r-metHuLeptin) therapy has been shown to be effective in treating metabolic abnormalities associated with congenital or acquired generalized lipodystrophy and PL associated with lamin A/C (LMNA) gene mutations or highly active antiretroviral… CONTINUE READING
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