Leptin suppression of insulin secretion by the activation of ATP-sensitive K+ channels in pancreatic beta-cells.

Abstract

In the genetic mutant mouse models ob/ob or db/db, leptin deficiency or resistance, respectively, results in severe obesity and the development of a syndrome resembling NIDDM. One of the earliest manifestations in these mutant mice is hyperinsulinemia, suggesting that leptin may normally directly suppress the secretion of insulin. Here, we show that… (More)

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Cite this paper

@article{Kieffer1997LeptinSO, title={Leptin suppression of insulin secretion by the activation of ATP-sensitive K+ channels in pancreatic beta-cells.}, author={Timothy J Kieffer and Rasmus Heller and Colin A. Leech and George G. Holz and Joel Francis Habener}, journal={Diabetes}, year={1997}, volume={46 6}, pages={1087-93} }