Leptin stimulation of COXIV is impaired in obese skeletal muscle myotubes.

@article{McAinch2007LeptinSO,
  title={Leptin stimulation of COXIV is impaired in obese skeletal muscle myotubes.},
  author={Andrew J. McAinch and Gregory R Steinberg and Janelle Mollica and Paul E. O'brien and J Brandon Dixon and Bruce E. Kemp and David Cameron-Smith},
  journal={Obesity research & clinical practice},
  year={2007},
  volume={1 1},
  pages={1-78}
}
SUMMARY OBJECTIVE To investigate the effects of leptin on the mRNA abundance of key genes involved in fatty acid oxidation and mitochondrial biogenesis in cultured skeletal muscle myotubes derived from lean and obese individuals. RESEARCH METHODS AND PROCEDURES Rectus abdominus muscle biopsies were obtained from surgical patients to establish primary skeletal muscle cell cultures. Two distinct primary cell culture groups were established (Lean and Obese) n = 7 in each group. Differentiated… CONTINUE READING
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