Leptin stimulates the oxidative burst in control monocytes but attenuates the oxidative burst in monocytes from HIV-infected patients.

@article{SnchezPozo2003LeptinST,
  title={Leptin stimulates the oxidative burst in control monocytes but attenuates the oxidative burst in monocytes from HIV-infected patients.},
  author={Cristina S{\'a}nchez-Pozo and Jes{\'u}s Rodr{\'i}guez-Ba{\~n}o and {\'A}ngel Dom{\'i}nguez-Castellano and Miguel Angel Munia{\'i}n and Raimundo Goberna and V{\'i}ctor S{\'a}nchez-Margalet},
  journal={Clinical and experimental immunology},
  year={2003},
  volume={134 3},
  pages={464-9}
}
Leptin, the 16 kDa product of the ob gene, is a an adipocyte-secreted hormone that centrally regulates weight. However, the physiological role of leptin is not limited to the regulation of food intake and energy expenditure, and leptin has a variety of effects in peripheral tissues, such as a regulatory role modulating the immune system. Thus, leptin receptor is expressed in human peripheral blood mononuclear cells, mediating the leptin stimulation of proliferation and activation, the… CONTINUE READING