Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase

  title={Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase},
  author={Y. Minokoshi and Young-Bum Kim and Odile D. Peroni and L. F. Fryer and C. Mueller and D. Carling and Barbara B. Kahn},
  • Y. Minokoshi, Young-Bum Kim, +4 authors Barbara B. Kahn
  • Published 2002
  • Chemistry, Medicine
  • Nature
  • Leptin is a hormone secreted by adipocytes that plays a pivotal role in regulating food intake, energy expenditure and neuroendocrine function. Leptin stimulates the oxidation of fatty acids and the uptake of glucose, and prevents the accumulation of lipids in nonadipose tissues, which can lead to functional impairments known as “lipotoxicity”. The signalling pathways that mediate the metabolic effects of leptin remain undefined. The 5′-AMP-activated protein kinase (AMPK) potently stimulates… CONTINUE READING
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