Leptin stimulates Xenopus lung development: evolution in a dish.

  title={Leptin stimulates Xenopus lung development: evolution in a dish.},
  author={John Steven Torday and Kaori Ihida-Stansbury and Virender K Rehan},
  journal={Evolution & development},
  volume={11 2},
The transition from uni- to multicellular organisms required metabolic cooperativity through cell-cell interactions mediated by soluble growth factors. We have empirically demonstrated such an integrating mechanism by which the metabolic hormone leptin stimulates lung development, causing the thinning of the gas exchange surface and the obligate increase in lung surfactant synthesis. All of these processes have occurred both phylogenetically and developmentally during the course of vertebrate… CONTINUE READING
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