Leptin reverses nonalcoholic steatohepatitis in patients with severe lipodystrophy.

  title={Leptin reverses nonalcoholic steatohepatitis in patients with severe lipodystrophy.},
  author={Edward D Javor and Marc G Ghany and E Cochran and Elif A Oral and Alex M Depaoli and Ahalya Premkumar and David E Kleiner and Phillip Gorden},
  volume={41 4},
Severe lipodystrophy is characterized by diminished adipose tissue and hypoleptinemia, leading to ectopic triglyceride accumulation. In the liver, this is associated with steatosis, potentially leading to nonalcoholic steatohepatitis (NASH). We investigated the prevalence of NASH and the effect of leptin replacement in these patients. Ten patients with either generalized lipodystrophy (8 patients) or Dunnigan's partial lipodystrophy (2 patients) were included in this analysis. Paired liver… CONTINUE READING


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