Leptin resistance - or why leptin fails to work in obesity.

  title={Leptin resistance - or why leptin fails to work in obesity.},
  author={K El-Haschimi and Hendrik Lehnert},
  journal={Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association},
  volume={111 1},
In experimental models of obesity high serum concentrations of leptin without subsequent inhibition of food intake indicate a resistance to the physiological effects of leptin. Similar to the animal model leptin concentrations in most of the obese patients are higher compared to normal-weight persons. The postulated leptin resistance is one major target in the search for a better understanding of obesity and the development of pharmacological tools to treat this spreading disease. 
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