Leptin resistance in obesity: An epigenetic landscape.

  title={Leptin resistance in obesity: An epigenetic landscape.},
  author={Ana B Crujeiras and Marcos C. Carreira and Bego{\~n}a Cabia and Sara Adri{\'a}n L{\'o}pez de Andrade and Mar{\'i}a Luisa Chas Amil and Felipe F F Casanueva},
  journal={Life sciences},
Leptin is an adipocyte-secreted hormone that inhibits food intake and stimulates energy expenditure through interactions with neuronal pathways in the brain, particularly pathways involving the hypothalamus. Intact functioning of the leptin route is required for body weight and energy homeostasis. Given its function, the discovery of leptin increased expectations for the treatment of obesity. However, most obese individuals and subjects with a predisposition to regain weight after losing it… CONTINUE READING
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Dietary factors

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  • epigenetic modifications and obesity outcomes…
  • 2015
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Differential modulation of arcuate nucleus andmesolimbic gene expression levels by central leptin in rats on short-term high-fat high-sugar diet

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