Leptin resistance: a possible interface of inflammation and metabolism in obesity-related cardiovascular disease.

@article{Martin2008LeptinRA,
  title={Leptin resistance: a possible interface of inflammation and metabolism in obesity-related cardiovascular disease.},
  author={Seth S. Martin and Atif Qasim and Muredach P. Reilly},
  journal={Journal of the American College of Cardiology},
  year={2008},
  volume={52 15},
  pages={1201-10}
}
Leptin is an adipocyte-derived hormone and cytokine that regulates energy balance through a wide range of functions, including several that are important to cardiovascular health. Increased circulating leptin, a marker of leptin resistance, is common in obesity and independently associated with insulin resistance and cardiovascular disease (CVD) in humans. The mechanisms of leptin resistance include genetic mutation, leptin self-regulation, limited tissue access, and cellular or circulating… CONTINUE READING
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