Leptin resistance: a possible interface of inflammation and metabolism in obesity-related cardiovascular disease.

  title={Leptin resistance: a possible interface of inflammation and metabolism in obesity-related cardiovascular disease.},
  author={Seth S. Martin and Atif Qasim and Muredach P. Reilly},
  journal={Journal of the American College of Cardiology},
  volume={52 15},
Leptin is an adipocyte-derived hormone and cytokine that regulates energy balance through a wide range of functions, including several that are important to cardiovascular health. Increased circulating leptin, a marker of leptin resistance, is common in obesity and independently associated with insulin resistance and cardiovascular disease (CVD) in humans. The mechanisms of leptin resistance include genetic mutation, leptin self-regulation, limited tissue access, and cellular or circulating… CONTINUE READING
Highly Influential
This paper has highly influenced 11 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS


Publications citing this paper.
Showing 1-10 of 162 extracted citations

Cardiometabolic risk markers of normal weight and excess body weight in Brazilian adolescents.

Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme • 2016
View 4 Excerpts
Highly Influenced

Oxytocin and cardioprotection in diabetes and obesity

BMC endocrine disorders • 2016
View 6 Excerpts
Highly Influenced

Inflammation and Oxidative Stress in Obesity-Related Glomerulopathy

International journal of nephrology • 2012
View 11 Excerpts
Highly Influenced


Publications referenced by this paper.
Showing 1-10 of 128 references

Role of leptin in immunity.

Cellular & molecular immunology • 2007
View 10 Excerpts
Highly Influenced

Adipokines, insulin resistance, and coronary artery calcification.

Journal of the American College of Cardiology • 2008
View 1 Excerpt

A prospective study of inflammatory cytokines and diabetes mellitus in a multiethnic cohort of postmenopausal women

AD Pradhan, JE Manson, N Rifai, JE Buring, PM Ridker
Arch Intern Med • 2007

Similar Papers

Loading similar papers…