Leptin requirement for conception, implantation, and gestation in the mouse.

@article{Malik2001LeptinRF,
  title={Leptin requirement for conception, implantation, and gestation in the mouse.},
  author={Nasser M. Malik and Nicholas D. Carter and Joanne F. Murray and Rex John Scaramuzzi and Catherine A. Wilson and Michael J. Stock},
  journal={Endocrinology},
  year={2001},
  volume={142 12},
  pages={5198-202}
}
The ob/ob mouse has a complete absence of circulating leptin, resulting in obesity and infertility. Using the minimum daily dose of leptin required to maintain normal body weight and sexual maturation (5 mg/kg, ip), leptin-treated ob/ob females were mated with either wild-type (+/+) or leptin-treated ob/ob males. The leptin treatment continued throughout pregnancy until weaning or was withdrawn at 0.5, 3.5, 6.5, or 14.5 d post coitum (dpc). Normal pregnancy and parturition with pups of normal… CONTINUE READING