Leptin regulation of proangiogenic molecules in benign and cancerous endometrial cells.

@article{Carino2008LeptinRO,
  title={Leptin regulation of proangiogenic molecules in benign and cancerous endometrial cells.},
  author={Cecilia Carino and Alexander B. Olawaiye and Salandre Cherfils and Takehiro Serikawa and Maureen P Lynch and Bo Ruben Rueda and Rub{\'e}n Ren{\'e} Gonz{\'a}lez},
  journal={International journal of cancer},
  year={2008},
  volume={123 12},
  pages={2782-90}
}
Several proangiogenic/proinflammatory factors involved in endometrial cancer are regulated by leptin, but the signaling mechanisms responsible for these leptin-induced actions are largely unknown. Here, we report that in benign (primary and HES) and cancerous-endometrial epithelial cells (EEC) (An3Ca, SK-UT2 and Ishikawa), leptin in a dose-dependent manner regulates vascular endothelial growth factor, (VEGF); interleukin-1 beta, (IL-1beta); leukemia inhibitory factor, (LIF) and their respective… CONTINUE READING
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