Leptin regulates neointima formation after arterial injury through mechanisms independent of blood pressure and the leptin receptor/STAT3 signaling pathways involved in energy balance.

@article{Bodary2007LeptinRN,
  title={Leptin regulates neointima formation after arterial injury through mechanisms independent of blood pressure and the leptin receptor/STAT3 signaling pathways involved in energy balance.},
  author={Peter F. Bodary and Yuechun Shen and Miina K Ohman and Kristina L Bahrou and Fernando B. Vargas and Sarah S Cudney and Kevin J Wickenheiser and Martin G Myers and Daniel T. Eitzman},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2007},
  volume={27 1},
  pages={70-6}
}
BACKGROUND Leptin is an adipocyte-derived hormone critical for energy homeostasis and implicated in vascular disease processes. The relevant cellular leptin receptor pools and signaling pathways involved in leptin-related vascular phenotypes in vivo are unclear. METHODS AND RESULTS Arterial injury was induced in wild-type (wt), leptin-deficient (lep(ob/ob)), and leptin receptor-deficient (lepr(db/db)) mice. Compared with wt mice, lep(ob/ob) and lepr(db/db) mice were protected from the… CONTINUE READING