Leptin regulates insulin sensitivity via phosphatidylinositol-3-OH kinase signaling in mediobasal hypothalamic neurons.

@article{Morton2005LeptinRI,
  title={Leptin regulates insulin sensitivity via phosphatidylinositol-3-OH kinase signaling in mediobasal hypothalamic neurons.},
  author={Gregory J. Morton and Richard Wayne Gelling and Kevin D. Niswender and Christopher D Morrison and Christopher J Rhodes and Michael J. Schwartz},
  journal={Cell metabolism},
  year={2005},
  volume={2 6},
  pages={411-20}
}
To investigate whether phosphatidylinositol-3 kinase (PI3K) signaling mediates the metabolic effects of hypothalamic leptin action, adenoviral gene therapy was used to direct expression of leptin receptors to the area of the hypothalamic arcuate nucleus (ARC). This intervention markedly improved insulin sensitivity in genetically obese, leptin-receptor-deficient Koletsky (fa(k)/fa(k)) rats via a mechanism that was not dependent on reduced food intake but was attenuated by approximately 44% by… CONTINUE READING
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