Leptin-regulated endocannabinoids are involved in maintaining food intake

@article{Marzo2001LeptinregulatedEA,
  title={Leptin-regulated endocannabinoids are involved in maintaining food intake},
  author={Vincenzo Di Marzo and Sravan Kumar Goparaju and Lei Wang and Jie Liu and Sandor Batkai and Zolt{\'a}n J{\'a}rai and Filomena Fezza and Grant I. Miura and Richard D. Palmiter and Takayuki Sugiura and George Kunos},
  journal={Nature},
  year={2001},
  volume={410},
  pages={822-825}
}
Leptin is the primary signal through which the hypothalamus senses nutritional state and modulates food intake and energy balance. Leptin reduces food intake by upregulating anorexigenic (appetite-reducing) neuropeptides, such as α-melanocyte-stimulating hormone, and downregulating orexigenic (appetite-stimulating) factors, primarily neuropeptide Y. Genetic defects in anorexigenic signalling, such as mutations in the melanocortin-4 (ref. 5) or leptin receptors, cause obesity. However… 
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