Leptin reduces pathology and improves memory in a transgenic mouse model of Alzheimer's disease.

@article{Greco2010LeptinRP,
  title={Leptin reduces pathology and improves memory in a transgenic mouse model of Alzheimer's disease.},
  author={Steven Greco and Kathryn J Bryan and Sraboni Sarkar and Xiongwei Zhu and Mark A. Smith and John Wesson Ashford and Jane M. Johnston and Nikolaos Tezapsidis and Gemma Casades{\'u}s},
  journal={Journal of Alzheimer's disease : JAD},
  year={2010},
  volume={19 4},
  pages={1155-67}
}
We have previously reported anti-amyloidogenic effects of leptin using in vitro and in vivo models and, more recently, demonstrated the ability of leptin to reduce tau phosphorylation in neuronal cells. The present study examined the efficacy of leptin in ameliorating the Alzheimer's disease (AD)-like pathology in 6-month old CRND8 transgenic mice (TgCRND8) following 8 weeks of treatment. Leptin-treated transgenic mice showed significantly reduced levels of amyloid-beta (Abeta){1-40} in both… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 4 times over the past 90 days. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 86 extracted citations

Similar Papers

Loading similar papers…