Leptin reduces Alzheimer's disease-related tau phosphorylation in neuronal cells.

@article{Greco2008LeptinRA,
  title={Leptin reduces Alzheimer's disease-related tau phosphorylation in neuronal cells.},
  author={Steven Greco and Sraboni Sarkar and Jane M. Johnston and Xiongwei Zhu and Bo Su and Gemma Casades{\'u}s and John Wesson Ashford and Mark A. Smith and Nikolaos Tezapsidis},
  journal={Biochemical and biophysical research communications},
  year={2008},
  volume={376 3},
  pages={536-41}
}
Leptin is a centrally acting hormone controlling metabolic pathways. Recently, it was shown that leptin can reduce amyloid beta levels both in vitro and in vivo. Herein, phosphorylation of tau was investigated following treatment of neuronal cells with leptin and insulin. Specifically, phosphorylation of tau at amino acid residues Ser(202), Ser(396) and Ser(404) was monitored in retinoic acid induced, human cell lines: SH-SY5Y and NTera-2. Both hormones induced a concentration- and time… CONTINUE READING