Leptin receptors are expressed in coronary arteries, and hyperleptinemia causes significant coronary endothelial dysfunction.

@article{Knudson2005LeptinRA,
  title={Leptin receptors are expressed in coronary arteries, and hyperleptinemia causes significant coronary endothelial dysfunction.},
  author={Jarrod D. Knudson and U. Deniz Dincer and Cuihua Zhang and Albert N. Swafford and Ryoji Koshida and Andrea Picchi and Marta Focardi and Gregory M. Dick and Johnathan D. Tune},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2005},
  volume={289 1},
  pages={
          H48-56
        }
}
Obesity is associated with marked increases in plasma leptin concentration, and hyperleptinemia is an independent risk factor for coronary artery disease. As a result, the purpose of this investigation was to test the following hypotheses: 1) leptin receptors are expressed in coronary endothelial cells; and 2) hyperleptinemia induces coronary endothelial dysfunction. RT-PCR analysis revealed that the leptin receptor gene is expressed in canine coronary arteries and human coronary endothelium… 
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Preliminary evidence suggests that leptin released from perivascular adipose tissue may also have deleterious effects on the underlying vasculature, including the coronary circulation, which is associated with increased incidence of cardiovascular pathologies.
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TLDR
Clinical studies have shown elevated plasma leptin in patients with essential hypertension and a significant positive correlation between leptin and blood pressure independent of body adiposity both in normotensive and in hypertensive individuals.
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TLDR
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