Leptin receptor in childhood acute leukemias.

  title={Leptin receptor in childhood acute leukemias.},
  author={E. G{\'o}rska and Katarzyna Popko and Maria Wąsik},
  journal={Advances in experimental medicine and biology},
Ob-R receptor is encoded by db gene and belongs to class I cytokine receptors family. Its expression was observed in hematopoietic CD34+ stem cells, erythropoietic, myeloid and lymphoblastic lineages cell lines and in human leukemic blast cells in lymphomas, acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL), and chronic myeloid leukemia (CML). The studies on human bone marrow cells show that JAK/STAT pathway plays a substantial role in signal transduction in young bone marrow… CONTINUE READING
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