Leptin-receptor-expressing neurons in the dorsomedial hypothalamus and median preoptic area regulate sympathetic brown adipose tissue circuits.

@article{Zhang2011LeptinreceptorexpressingNI,
  title={Leptin-receptor-expressing neurons in the dorsomedial hypothalamus and median preoptic area regulate sympathetic brown adipose tissue circuits.},
  author={Yan Zhang and Ilan A. Kerman and Amanda Laque and Phillip Q. Nguyen and Miro A Faouzi and Gwendolyn W. Louis and Justin C. Jones and Christopher J Rhodes and Heike M{\"u}nzberg},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2011},
  volume={31 5},
  pages={1873-84}
}
Brown adipose tissue (BAT) thermogenesis is critical to maintain homoeothermia and is centrally controlled via sympathetic outputs. Body temperature and BAT activity also impact energy expenditure, and obesity is commonly associated with decreased BAT capacity and sympathetic tone. Severely obese mice that lack leptin or its receptor (LepRb) show decreased BAT capacity, sympathetic tone, and body temperature and thus are unable to adapt to acute cold exposure (Trayhurn et al., 1976). LepRb… CONTINUE READING