Leptin receptor-expressing bone marrow stromal cells are myofibroblasts in primary myelofibrosis

@inproceedings{Decker2017LeptinRB,
  title={Leptin receptor-expressing bone marrow stromal cells are myofibroblasts in primary myelofibrosis},
  author={Matthew Decker and Leticia Mart{\'i}nez-Morentin and Guannan Wang and Yeojin Lee and Qingxue Liu and Juliana S. Leslie and Lei Ding},
  booktitle={Nature Cell Biology},
  year={2017}
}
Bone marrow fibrosis is a critical component of primary myelofibrosis (PMF). However, the origin of the myofibroblasts that drive fibrosis is unknown. Using genetic fate mapping we found that bone marrow leptin receptor (Lepr)-expressing mesenchymal stromal lineage cells expanded extensively and were the fibrogenic cells in PMF. These stromal cells downregulated the expression of key haematopoietic-stem-cell-supporting factors and upregulated genes associated with fibrosis and osteogenesis… CONTINUE READING
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