Leptin receptor-deficient obese Zucker rats reduce their food intake in response to hypobaric hypoxia.

  title={Leptin receptor-deficient obese Zucker rats reduce their food intake in response to hypobaric hypoxia.},
  author={Nadine Simler and Alexandra Grosfeld and Andr{\'e} Peinnequin and Mich{\'e}le Guerre-Millo and A X Bigard},
  journal={American journal of physiology. Endocrinology and metabolism},
  volume={290 3},
Exposure to hypoxia induces anorexia in humans and rodents, but the role of leptin remains under discussion and that of orexigenic and anorexigenic hypothalamic neuropeptides remains unknown. The present study was designed to address this issue by using obese (Lepr(fa)/Lepr(fa)) Zucker rats, a rat model of genetic leptin receptor deficiency. Homozygous lean (Lepr(FA)/Lepr(FA)) and obese (Lepr(fa)/Lepr(fa)) rats were randomly assigned to two groups, either kept at ambient pressure or exposed to… CONTINUE READING
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