Leptin receptor antagonism of iNKT cell function: a novel strategy to combat multiple myeloma

Abstract

A hallmark of bone marrow changes with aging is the increase in adipocyte composition, but how this impacts development of multiple myeloma (MM) is unknown. Here, we report the role of the adipokine leptin as master regulator of anti-myeloma tumor immunity by modulating the invariant natural killer T (iNKT) cell function. A marked increase in serum leptin… (More)
DOI: 10.1038/leu.2017.146

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@article{Favreau2017LeptinRA, title={Leptin receptor antagonism of iNKT cell function: a novel strategy to combat multiple myeloma}, author={M{\'e}r{\'e}dis Favreau and Eric Menu and Djoere Gaublomme and Karen Vanderkerken and Sebastian Faict and Katrien Maes and Elke De Bruyne and S. Govindarajan and Martin Drennan and Serge van Calenbergh and Xavier Leleu and Lennart Zabeau and J. Tavernier and Katrien Venken and Dirk Elewaut}, journal={Leukemia}, year={2017}, volume={31}, pages={2678-2685} }