Leptin rapidly improves glucose homeostasis in obese mice by increasing hypothalamic insulin sensitivity.

@article{Koch2010LeptinRI,
  title={Leptin rapidly improves glucose homeostasis in obese mice by increasing hypothalamic insulin sensitivity.},
  author={Christiane E. Koch and Rachael A Augustine and J. Ryan Steger and Goutham Kumar Ganjam and Jonas Benzler and Corinna Pracht and Chrishanthi Lowe and Michael J. Schwartz and P. R. Shepherd and Greg M Anderson and David R Grattan and A Tups},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2010},
  volume={30 48},
  pages={16180-7}
}
Obesity is associated with resistance to the actions of both leptin and insulin via mechanisms that remain incompletely understood. To investigate whether leptin resistance per se contributes to insulin resistance and impaired glucose homeostasis, we investigated the effect of acute leptin administration on glucose homeostasis in normal as well as leptin- or leptin receptor-deficient mice. In hyperglycemic, leptin-deficient Lep(ob/ob) mice, leptin acutely and potently improved glucose… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 1 time over the past 90 days. VIEW TWEETS