Leptin protects the pancreas from damage induced by caerulein overstimulation by modulating cytokine production.

@article{Jaworek2002LeptinPT,
  title={Leptin protects the pancreas from damage induced by caerulein overstimulation by modulating cytokine production.},
  author={Jolanta Jaworek and Joanna Bonior and Piotr Pierzchalski and Romana A Tomaszewska and Jerzy Stachura and Ryszard Sendur and Anna Leja and Bożena Jachimczak and Piotr Ch. Konturek and Władysław Bielański and Wiesław W. Pawlik and Stanisław Jan Konturek},
  journal={Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]},
  year={2002},
  volume={2 2},
  pages={
          89-99
        }
}
BACKGROUND Recent identification of specific leptin receptors in the pancreas suggests that this peptide may also play some role in this gland. AIM To examine the effect of intraperitoneal (i.p.) or intracerebroventricular (i.c.v.) administration of leptin in rats on caerulein-induced pancreatitis (CIP), pancreatic gene expression of leptin and inflammatory cytokine production. METHODS Caerulein (25 micrograms/kg) was infused subcutaneously into conscious rats over 5 h to produce CIP… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 22 CITATIONS

Similar Papers

Loading similar papers…