Leptin promotes metastasis by inducing an epithelial-mesenchymal transition in A549 lung cancer cells.

@article{Feng2013LeptinPM,
  title={Leptin promotes metastasis by inducing an epithelial-mesenchymal transition in A549 lung cancer cells.},
  author={Helin Feng and Qingyi Liu and Ning Zhang and Lihua Zheng and Meixiang Sang and Jiangang Feng and Jinming Zhang and Xiangyun Wu and Bao-en Shan},
  journal={Oncology research},
  year={2013},
  volume={21 3},
  pages={165-71}
}
Leptin, an adipocyte-derived cytokine associated with obesity, has been reported to participate in carcinogenesis. Epithelial-mesenchymal transition (EMT) is also considered as a key event in tumor metastasis. The aim of this study is to investigate the mechanism of leptin in the promotion of EMT leading to metastasis in A549 lung cancer cells. We investigated the effect of leptin on migration of A549 cells using wound healing and transwell assays. The incidence of EMT in A549 cells was… CONTINUE READING
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