Leptin production during early starvation in lean and obese women.

  title={Leptin production during early starvation in lean and obese women.},
  author={Samuel Klein and Jeffrey F. Horowitz and Michael L Landt and S J Goodrick and Vidya Mohamed-Ali and Simon Ward Coppack},
  journal={American journal of physiology. Endocrinology and metabolism},
  volume={278 2},
We evaluated abdominal adipose tissue leptin production during short-term fasting in nine lean [body mass index (BMI) 21 +/- 1 kg/m(2)] and nine upper body obese (BMI 36 +/- 1 kg/m(2)) women. Leptin kinetics were determined by arteriovenous balance across abdominal subcutaneous adipose tissue at 14 and 22 h of fasting. At 14 h of fasting, net leptin release from abdominal adipose tissue in obese subjects (10.9 +/- 1.9 ng x 100 g tissue x (-1) x min(-1)) was not significantly greater than the… CONTINUE READING
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