Leptin modulates extracellular matrix molecules and metalloproteinases: possible implications for trophoblast invasion.

@article{Castellucci2000LeptinME,
  title={Leptin modulates extracellular matrix molecules and metalloproteinases: possible implications for trophoblast invasion.},
  author={Mario Castellucci and Rita De Matteis and Arielle Meisser and Raffaella Cancello and Vladia Monsurr{\'o} and D. Islami and Riccardo Sarzani and Daniela Marzioni and Saverio Cinti and Paul Bischof},
  journal={Molecular human reproduction},
  year={2000},
  volume={6 10},
  pages={951-8}
}
Leptin is a circulating hormone which plays an important role in the regulation of energy balance, haemopoiesis and reproduction. Leptin and its receptor (leptin-R) are localized in human placental tissue but their function is not known. In this study we have investigated the expression of leptin and leptin-R in the human placenta with particular attention to extravillous cytotrophoblastic cell islands and cell columns which play a pivotal role in trophoblast invasion and placental growth. We… CONTINUE READING

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