Leptin modulates beta cell expression of IL-1 receptor antagonist and release of IL-1beta in human islets.

@article{Maedler2004LeptinMB,
  title={Leptin modulates beta cell expression of IL-1 receptor antagonist and release of IL-1beta in human islets.},
  author={Kathrin Maedler and Pavel Sergeev and Jan Adam Ehses and Zolt{\'a}n M{\'a}th{\'e} and Domenico Bosco and Thierry Berney and J A Dayer and Manfred Reinecke and Philippe A. Halban and Marc Yves Donath},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2004},
  volume={101 21},
  pages={8138-43}
}
High concentrations of glucose induce beta cell production of IL-1beta, leading to impaired beta cell function and apoptosis in human pancreatic islets. IL-1 receptor antagonist (IL-1Ra) is a naturally occurring antagonist of IL-1beta and protects cultured human islets from glucotoxicity. Therefore, the balance of IL-1beta and IL-1Ra may play a crucial role in the pathogenesis of diabetes. In the present study, we observed expression of IL-1Ra in human pancreatic beta cells of nondiabetic… CONTINUE READING

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