Leptin mediates the parathyroid hormone-related protein paracrine stimulation of fetal lung maturation.

@article{Torday2002LeptinMT,
  title={Leptin mediates the parathyroid hormone-related protein paracrine stimulation of fetal lung maturation.},
  author={John Steven Torday and Huanxing Sun and Lei Wang and Eric Torres and Mary E. Sunday and Lewis P. Rubin},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2002},
  volume={282 3},
  pages={L405-10}
}
Developing rat lung lipofibroblasts express leptin beginning on embryonic day (E) 17, increasing 7- to 10-fold by E20. Leptin and its receptor are expressed mutually exclusively by fetal lung fibroblasts and type II cells, suggesting a paracrine signaling "loop." This hypothesized mechanism is supported by the following experimental data: 1) leptin stimulates the de novo synthesis of surfactant phospholipid by both fetal rat type II cells (400% x 100 ng(-1) x ml(-1) x 24 h(-1)) and adult human… CONTINUE READING
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