Leptin is key to peroxynitrite-mediated oxidative stress and Kupffer cell activation in experimental non-alcoholic steatohepatitis.

@article{Chatterjee2013LeptinIK,
  title={Leptin is key to peroxynitrite-mediated oxidative stress and Kupffer cell activation in experimental non-alcoholic steatohepatitis.},
  author={Saurabh Chatterjee and Douglas Ganini and Erik J. Tokar and Ashutosh Kumar and Suvarthi Das and Jean Corbett and Maria B. Kadiiska and Michael P. Waalkes and Anna Mae Diehl and Ronald Paul Mason},
  journal={Journal of hepatology},
  year={2013},
  volume={58 4},
  pages={
          778-84
        }
}
BACKGROUND & AIMS Progression from steatosis to steatohepatitic lesions is hypothesized to require a second hit. These lesions have been associated with increased oxidative stress, often ascribed to high levels of leptin and other proinflammatory mediators. Here we have examined the role of leptin in inducing oxidative stress and Kupffer cell activation in CCl4-mediated steatohepatitic lesions of obese mice. METHODS Male C57BL/6 mice fed with a high-fat diet (60%kcal) at 16 weeks were… CONTINUE READING
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P2x7 receptor-NADPH oxidase-axis mediates protein radical formation and Journal of Hepatology 201 Please cite this article in press

  • S Chatterjee, R Rana, J Corbett, MB Kadiiska, J Goldstein, RP. Mason
  • J Hepatol
  • 2013
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