Leptin is inversely related to age at menarche in human females.

@article{Matkovic1997LeptinII,
  title={Leptin is inversely related to age at menarche in human females.},
  author={Velimir Matkovic and Jasminka Z. Ilich and Mario Skugor and N. E. Badenhop and Prem K. Goel and Albert C. Clairmont and Dino D. Klisovic and Ramzi W. Nahhas and John D. Landoll},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1997},
  volume={82 10},
  pages={
          3239-45
        }
}
Over the last century there has been a trend toward an earlier onset of menarche attributed to better nutrition and body fatness. With the discovery of the obesity gene and its product, leptin, we reexamined this hypothesis from a new perspective. As delayed menarche and leanness are considered risk factors for osteoporosis, we also evaluated the relation between leptin and bone mass. Body composition and serum leptin levels were measured, and the timing of menarche was recorded in 343 pubertal… CONTINUE READING
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