Leptin is expressed in and secreted from primary cultures of human osteoblasts and promotes bone mineralization.

@article{Reseland2001LeptinIE,
  title={Leptin is expressed in and secreted from primary cultures of human osteoblasts and promotes bone mineralization.},
  author={Janne E Reseland and Unni Syversen and Ingunn Bakke and Gunnar Qvigstad and Lars Eide and Oyvind Hjertner and Jan Oxholm Gordeladze and Christian A. Drevon},
  journal={Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  year={2001},
  volume={16 8},
  pages={1426-33}
}
The adipose hormone leptin and its receptor are important for regulation of food intake and energy metabolism. Leptin also is involved in the growth of different tissues. In this study, we show the expression of leptin in primary cultures of normal human osteoblasts (hOBs) as evidenced by reverse transcriptase-polymerase chain reaction (RT-PCR) and immunocytochemistry. Release of leptin into the medium also was found. Leptin was not detected in commercially available hOBs (NHOst) or in three… CONTINUE READING