Leptin is essential for the hepatic fibrogenic response to chronic liver injury.

@article{Leclercq2002LeptinIE,
  title={Leptin is essential for the hepatic fibrogenic response to chronic liver injury.},
  author={Isabelle A Leclercq and Geoffrey C. Farrell and Rixt Schriemer and Graham R. Robertson},
  journal={Journal of hepatology},
  year={2002},
  volume={37 2},
  pages={206-13}
}
BACKGROUND/AIMS Obesity is associated with hyperleptinemia and is also a risk factor for fibrosis and severity of fibrosis in several chronic liver diseases. The correlation between increased leptin, obesity and hepatic fibrosis prompted us to hypothesise that leptin has profibrogenic effects on the liver. METHODS We analysed the role of leptin in liver fibrosis in leptin-deficient mice fed a diet which generates steatohepatitis, and in chronic carbon tetrachloride-induced hepatic injury… CONTINUE READING
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