Leptin inhibits swallowing in rats.

@article{Flix2006LeptinIS,
  title={Leptin inhibits swallowing in rats.},
  author={Bernadette F{\'e}lix and André Jean and Claude Roman},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  year={2006},
  volume={291 3},
  pages={
          R657-63
        }
}
  • B. FélixA. JeanC. Roman
  • Published 1 September 2006
  • Biology, Psychology
  • American journal of physiology. Regulatory, integrative and comparative physiology
Swallowing is under the control of premotoneurons located in the medullary solitary tract nucleus. Although rats with transected midbrain do not seek out food, they are able to ingest food present near the mouth, and acute food deprivation induces an increase in food intake. Leptin is a satiety signal that regulates feeding behavior. Because leptin receptors are found within the caudal brainstem, and because food intake is regulated in midbrain transected rats, this study tested the hypothesis… 
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53 References

Identification of the medullary swallowing regions in the rat

It is concluded that the swallowing neurons studied belonged to the medullary swallowing center; the group II neurons were motoneurons and interneurons forming the efferent stage of the swallowing center, and the group I neurons were the interneURons which largely belong to the center which programs the swallowing motor sequence.

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Results provide evidence that swallowing can be induced by activation of EAA receptors of both the NMDA and the non-NMDA subclasses located within the NTS, and indicate that both subclasses may still be active in ketamine-anesthetized animals.

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The neuronal circuitry, the cellular properties of neurons, and the neurotransmitters possibly involved, as well as the peripheral and central inputs which shape the output of the network appropriately so that the swallowing movements correspond to the bolus to be swallowed are analyzed.

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It is suggested that gastric leptin has a significantly stronger effect in the 7- to 8-day-old animals than in the younger neonates, and peripheral Gastric leptin modulates brain stem neuronal activity.

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