Leptin inhibits gonadotrophin-stimulated granulosa cell progesterone production by antagonizing insulin action.

@article{Brannian1999LeptinIG,
  title={Leptin inhibits gonadotrophin-stimulated granulosa cell progesterone production by antagonizing insulin action.},
  author={John D Brannian and Yangyu Zhao and Maire McElroy},
  journal={Human reproduction},
  year={1999},
  volume={14 6},
  pages={1445-8}
}
Recent evidence has demonstrated that expression of leptin and leptin receptors is expected in the human ovary, and that leptin alters ovarian steroidogenesis in animal models. This study was designed to determine whether leptin modulates basal, gonadotrophin-, and insulin-stimulated progesterone production by human luteinized granulosa cells (GC). GC were recovered from follicular aspirates obtained during transvaginal ultrasound-guided oocyte retrieval for in-vitro fertilization-embryo… CONTINUE READING