Leptin inhibits epileptiform-like activity in rat hippocampal neurones via PI 3-kinase-driven activation of BK channels.

@article{Shanley2002LeptinIE,
  title={Leptin inhibits epileptiform-like activity in rat hippocampal neurones via PI 3-kinase-driven activation of BK channels.},
  author={Lynne J. Shanley and Dervla O'Malley and Andrew J. Irving and Michael L J Ashford and Jenni Harvey},
  journal={The Journal of physiology},
  year={2002},
  volume={545 3},
  pages={
          933-44
        }
}
The obese gene product, leptin is an important circulating satiety factor that regulates energy balance via its actions in the hypothalamus. However, leptin receptors are also expressed in brain regions not directly associated with energy homeostasis, such as the hippocampus. Here, leptin inhibits hippocampal neurones via activation of large conductance Ca(2+)-activated K(+) (BK) channels, a process that may be important in regulating neuronal excitability. We now show that leptin receptor… CONTINUE READING

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