Leptin inhibits bone formation not only in rodents, but also in sheep.

@article{Pogoda2006LeptinIB,
  title={Leptin inhibits bone formation not only in rodents, but also in sheep.},
  author={Pia Pogoda and Marcus Egermann and Johann C Schnell and Matthias H Priemel and Arndt F. Schilling and Mauro Alini and Thorsten Schinke and Johannes R{\"u}ger and Erich Schneider and Iain Clarke and Michael Amling},
  journal={Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  year={2006},
  volume={21 10},
  pages={1591-9}
}
UNLABELLED This study examines the effect of long-term ICV administration of leptin in ewes. We found that central application significantly decreased osteoblast activity as measured by serum analysis as well as by histomorphometry, resulting in decreased trabecular bone volume. These data provide additional evidence that bone formation and therefore bone remodeling is at least in part centrally controlled. INTRODUCTION Genetic studies in mice have identified leptin as a potent inhibitor of… CONTINUE READING
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