Leptin induces upregulation of sphingosine kinase 1 in oestrogen receptor-negative breast cancer via Src family kinase-mediated, janus kinase 2-independent pathway

@inproceedings{Alshaker2014LeptinIU,
  title={Leptin induces upregulation of sphingosine kinase 1 in oestrogen receptor-negative breast cancer via Src family kinase-mediated, janus kinase 2-independent pathway},
  author={Heba Audai Alshaker and Jonathan Krell and Adam E Frampton and Jonathan A. Waxman and Oleg Blyuss and Alexey Zaikin and Mathias H. Winkler and Justin Stebbing and Ernesto Yag{\"u}e and Dmitri Pchejetski},
  booktitle={Breast Cancer Research},
  year={2014}
}
Obesity is a known risk factor for breast cancer. Sphingosine kinase 1 (SK1) is an oncogenic lipid kinase that is overexpressed in breast tumours and linked with poor prognosis, however, its role in obesity-driven breast cancer was never elucidated. Human primary and secondary breast cancer tissues were analysed for SK1 and leptin receptor expression using quantitative real-time polymerase chain reaction (qRT-PCR) assay. Leptin-induced signalling was analysed in human oestrogen receptor (ER… CONTINUE READING
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