Leptin induces migration and invasion of glioma cells through MMP-13 production.


Leptin, the product of the obese gene, plays an important role in the regulation of body weight by coordinating metabolism, feeding behavior, energy balance, and neuroendocrine responses. However, regulation of leptin gene expression in the central nervous system is different from that in the adipocytes. In addition, leptin has been found in many tumor cell… (More)
DOI: 10.1002/glia.20773


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