Leptin induces growth hormone secretion from peripheral blood mononuclear cells via a protein kinase C- and nitric oxide-dependent mechanism.

@article{Dixit2003LeptinIG,
  title={Leptin induces growth hormone secretion from peripheral blood mononuclear cells via a protein kinase C- and nitric oxide-dependent mechanism.},
  author={Vishwa Deep Dixit and Manfred Mielenz and Dennis D. Taub and Nahid Parvizi},
  journal={Endocrinology},
  year={2003},
  volume={144 12},
  pages={5595-603}
}
Leptin is a key mediator of signals regulating food intake and energy expenditure and exerts potent immunomodulatory effects. We investigated the mechanisms mediating the action of leptin on GH secretion from peripheral blood mononuclear cells (PBMCs). Using immunofluorescence microscopy, we demonstrated a polarized expression pattern of leptin receptor protein on the surface of mononuclear cells and constitutive expression of GH in PBMCs. Leptin exhibited a dose-dependent stimulatory effect on… CONTINUE READING

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