Leptin induces apoptosis via ERK/cPLA2/cytochrome c pathway in human bone marrow stromal cells.

@article{Kim2003LeptinIA,
  title={Leptin induces apoptosis via ERK/cPLA2/cytochrome c pathway in human bone marrow stromal cells.},
  author={Ghi Su Kim and Jeong Soo Hong and Seung Wook Kim and Chung Sun An and Su-Li Cheng},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 24},
  pages={
          21920-9
        }
}
Leptin, the Ob gene product, has emerged recently as a key regulator of bone mass. However, the mechanism mediating leptin effect remains controversial. Because the action of leptin is dependent on its receptors, we analyzed their expression in osteoblast-lineage primary human bone marrow stromal cells (hBMSC). Both the short and long forms of leptin receptors were detected in hBMSC. Leptin significantly decreased the viability of hBMSC. This cytotoxic effect was prevented by Z-Val-Ala-Asp… CONTINUE READING
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