Leptin-induced mitochondrial fusion mediates hepatic lipid accumulation

  title={Leptin-induced mitochondrial fusion mediates hepatic lipid accumulation},
  author={W-H Hsu and B Lee and T-M Pan},
  journal={International Journal of Obesity},
Background:Leptin alleviates metabolic conditions such as insulin resistance and obesity, although the precise mechanism of action is unclear. Mitochondrial fusion/fission states affect energy balance, but the association between mitochondrial fusion and lipid metabolism is also unknown. The aim of this study was to determine whether mitochondrial fusion/fission state regulates lipid accumulation and to understand the role of leptin in mitochondrial function and its mechanism of action in… CONTINUE READING
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