Leptin-induced mTOR activation defines a specific molecular and transcriptional signature controlling CD4+ effector T cell responses.

@article{Procaccini2012LeptininducedMA,
  title={Leptin-induced mTOR activation defines a specific molecular and transcriptional signature controlling CD4+ effector T cell responses.},
  author={Claudio Procaccini and Veronica De Rosa and Mario Galgani and Fortunata Carbone and Silvana Cassano and Dario Greco and Kui Qian and Petri Auvinen and Gaetano Cal{\`i} and Giovanni Stallone and Luigi Formisano and Antonio La Cava and Giuseppe Matarese},
  journal={Journal of immunology},
  year={2012},
  volume={189 6},
  pages={
          2941-53
        }
}
The sensing by T cells of metabolic and energetic changes in the microenvironment can determine the differentiation, maturation, and activation of these cells. Although it is known that mammalian target of rapamycin (mTOR) gauges nutritonal and energetic signals in the extracellular milieu, it is not known how mTOR and metabolism influence CD4+CD25-FOXP3- effector T cell (Teff) responses. In this article, we show that leptin-induced activation of mTOR, which, in turn, controls leptin production… CONTINUE READING

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