Leptin-induced ER-α-positive breast cancer cell viability and migration is mediated by suppressing CCN5-signaling via activating JAK/AKT/STAT-pathway

@article{Haque2018LeptininducedEB,
  title={Leptin-induced ER-$\alpha$-positive breast cancer cell viability and migration is mediated by suppressing CCN5-signaling via activating JAK/AKT/STAT-pathway},
  author={Inamul Haque and Arnab Ghosh and Seth Acup and Snigdha Banerjee and Kakali Dhar and Amitabha Ray and Sandipto Sarkar and Suman Kambhampati and Sushanta K Banerjee},
  journal={BMC Cancer},
  year={2018},
  volume={18}
}
BackgroundIn menopausal women, one of the critical risk factors for breast cancer is obesity/adiposity. It is evident from various studies that leptin, a 16 kDa protein hormone overproduced in obese people, plays the critical role in neovascularization and tumorigenesis in breast and other organs. However, the mechanisms by which obesity influences the breast carcinogenesis remained unclear. In this study, by analyzing different estrogen receptor-α (ER-α)-positive and ER-α-negative BC cell… 
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References

SHOWING 1-10 OF 97 REFERENCES
Activation of IL-8 via PI3K/Akt-dependent pathway is involved in leptin-mediated epithelial-mesenchymal transition in human breast cancer cells
TLDR
It is demonstrated that leptin-induced EMT in breast cancer cells requires IL-8 activation via the PI3K/Akt signal pathway and in vivo xenograft experiment revealed that leptin signally promoted tumor growth and metastasis and increased the expressions ofIL-8 and EMT-related biomarkers.
Leptin promotes epithelial-mesenchymal transition of breast cancer via the upregulation of pyruvate kinase M2
TLDR
The data suggest that leptin promotes EMT in breast cancer cells via the upregulation of PKM2 expression as well as activation of PI3K/AKT signaling pathway, andPKM2 might be one of the key points and potential targets for breast cancer therapy.
Leptin-induced Epithelial-Mesenchymal Transition in Breast Cancer Cells Requires β-Catenin Activation via Akt/GSK3- and MTA1/Wnt1 Protein-dependent Pathways*
TLDR
Molecular evidence is provided that leptin induces breast cancer cells to undergo a transition from epithelial to spindle-like mesenchymal morphology and identifies an important modifier of Wnt1 signaling, MTA1, which is integral to leptin-mediated regulation of the Wnt/β-catenin pathway.
Leptin-regulated gene expression in MCF-7 breast cancer cells: mechanistic insights into leptin-regulated mammary tumor growth and progression.
TLDR
The identification of leptin-regulated genes in hormone-responsive Michigan Cancer Foundation-7 (MCF-7) human breast cancer cells is described to provide mechanistic links into the relationship between obesity and breast cancer incidence and morbidity.
Bidirectional crosstalk between leptin and insulin-like growth factor-I signaling promotes invasion and migration of breast cancer cells via transactivation of epidermal growth factor receptor.
TLDR
A novel bidirectional crosstalk between leptin and IGF-I signaling that transactivates EGFR and promotes the metastatic properties as well as invasion and migration of breast cancer cells is suggested.
Estrogen Receptor-α in the Inhibition of Cancer Growth and Angiogenesis
TLDR
It is shown that, unlike estradiol, high levels of ER-α significantly inhibit the growth of tumors xenografted from the Ishikawa cells and, in vivo down-regulation of vascular endothelial growth factor was observed in tumor xenografts.
Increased Expression of Leptin and the Leptin Receptor as a Marker of Breast Cancer Progression: Possible Role of Obesity-Related Stimuli
TLDR
Leptin and ObR are overexpressed in breast cancer, possibly due to hypoxia and/ or overexposure of cells to insulin, IGF-I, and/or estradiol.
Leptin Induces, via ERK1/ERK2 Signal, Functional Activation of Estrogen Receptor α in MCF-7 Cells*
TLDR
It is demonstrated that leptin induces aromatase activity in MCF-7 cells evidencing its important role in enhancing in situ estradiol production and promoting estrogen-dependent breast cancer progression.
Glucocorticoids induce CCN5/WISP-2 expression and attenuate invasion in oestrogen receptor-negative human breast cancer cells.
TLDR
The results indicate that glucocorticoid treatment of ER-negative breast cancer cells induces high levels of CCN5 expression and is accompanied by the appearance of a more differentiated and less invasive epithelial phenotype, which proposes a novel therapeutic strategy for high-risk breast cancer patients.
Leptin produced by obese adipose stromal/stem cells enhances proliferation and metastasis of estrogen receptor positive breast cancers
TLDR
This study provides mechanistic insight as to how obesity enhances the proliferation and metastasis of Breast cancer cells; specifically, obASC-derived leptin contributes to the aggressiveness of breast cancer in obese women.
...
1
2
3
4
5
...