Leptin increases hypothalamic pro-opiomelanocortin mRNA expression in the rostral arcuate nucleus.

@article{Schwartz1997LeptinIH,
  title={Leptin increases hypothalamic pro-opiomelanocortin mRNA expression in the rostral arcuate nucleus.},
  author={Michael J. Schwartz and Randy J Seeley and Stephen Woods and David S. Weigle and L. Arthur Campfield and P James Burn and Denis G. Baskin},
  journal={Diabetes},
  year={1997},
  volume={46 12},
  pages={2119-23}
}
Melanocortins are peptides, cleaved from the pro-opiomelanocortin (POMC) precursor, that act in the brain to reduce food intake and are potential mediators of leptin action. In the forebrain, melanocortins are derived from POMC-containing neurons of the hypothalamic arcuate nucleus. To test the hypothesis that these POMC neurons are regulated by leptin, we used in situ hybridization to determine whether reduced leptin signaling (as occurs in fasting), genetic leptin deficiency (in obese ob/ob… CONTINUE READING
Highly Influential
This paper has highly influenced 18 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 314 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 29 references

Similar Papers

Loading similar papers…