Leptin in the regulation of immunity, inflammation, and hematopoiesis.

@article{Fantuzzi2000LeptinIT,
  title={Leptin in the regulation of immunity, inflammation, and hematopoiesis.},
  author={Giamila Fantuzzi and Raffaella Faggioni},
  journal={Journal of leukocyte biology},
  year={2000},
  volume={68 4},
  pages={
          437-46
        }
}
Leptin, the product of the ob gene, is a pleiotropic molecule that regulates food intake as well as metabolic and endocrine functions. Leptin also plays a regulatory role in immunity, inflammation, and hematopoiesis. Alterations in immune and inflammatory responses are present in leptin- or leptin-receptor-deficient animals, as well as during starvation and malnutrition, two conditions characterized by low levels of circulating leptin. Both leptin and its receptor share structural and… CONTINUE READING

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