Leptin in the interplay of inflammation, metabolism and immune system disorders

  title={Leptin in the interplay of inflammation, metabolism and immune system disorders},
  author={Vanessa Abella and Morena Scotece and Javier Conde and Jes{\'u}s Pino and Miguel A Gonz{\'a}lez-Gay and Juan J G{\'o}mez-Reino and Antonio Chamorro Mera and Francisca Lago and Rodolfo G{\'o}mez and Oreste Gualillo},
  journal={Nature Reviews Rheumatology},
Leptin is one of the most relevant factors secreted by adipose tissue and the forerunner of a class of molecules collectively called adipokines. Initially discovered in 1994, its crucial role as a central regulator in energy homeostasis has been largely described during the past 20 years. Once secreted into the circulation, leptin reaches the central and peripheral nervous systems and acts by binding and activating the long form of leptin receptor (LEPR), regulating appetite and food intake… CONTINUE READING
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