Leptin enhances endothelial cell differentiation and angiogenesis in murine embryonic stem cells.

@article{Kurtovic2015LeptinEE,
  title={Leptin enhances endothelial cell differentiation and angiogenesis in murine embryonic stem cells.},
  author={Silvia Kurtovic and Tina T. Ng and Ankur Gupta and Vaithilingaraja Arumugaswami and Kira L Chaiboonma and Mohammad Amin Aminzadeh and Raj R. Makkar and Donald C. Dafoe and Dodanim Talavera-Adame},
  journal={Microvascular research},
  year={2015},
  volume={97},
  pages={65-74}
}
The metabolic regulation of leptin and its angiogenic effects have been well characterized in adult mammals. However, the role of leptin in the differentiation of embryonic stem cells (ESCs) to endothelial cells (ECs) has not been characterized. We hypothesized that leptin enhances the generation of ECs derived from ESCs and, in this way, promotes… CONTINUE READING