Leptin enhances NMDA receptor function and modulates hippocampal synaptic plasticity.

@article{Shanley2001LeptinEN,
  title={Leptin enhances NMDA receptor function and modulates hippocampal synaptic plasticity.},
  author={Lynne J. Shanley and Andrew J. Irving and Jenni Harvey},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2001},
  volume={21 24},
  pages={
          RC186
        }
}
The obese gene product leptin is an important signaling protein that regulates food intake and body weight via activation of the hypothalamic leptin receptor (Ob-Rb; Jacob et al., 1997). However, there is growing evidence that Ob-Rb is also expressed in CNS regions, not directly associated with energy homeostasis (Mercer et al., 1996; Hakansson et al., 1998). In the hippocampus, an area of the brain involved in learning and memory, we have found that leptin facilitates the induction of synaptic… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 169 CITATIONS

Cognitive Impairment Due to Leptin Withdrawal in Rat Offspring of Dams with Maternal Diet-Induced Obesity

  • Medical science monitor : international medical journal of experimental and clinical research
  • 2018
VIEW 7 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

A Leptin Fragment Mirrors the Cognitive Enhancing and Neuroprotective Actions of Leptin.

  • Cerebral cortex
  • 2017
VIEW 6 EXCERPTS
CITES BACKGROUND, RESULTS & METHODS
HIGHLY INFLUENCED

NMDA receptor subunit composition determines the polarity of leptin-induced synaptic plasticity

  • Neuropharmacology
  • 2011
VIEW 15 EXCERPTS
CITES METHODS, BACKGROUND & RESULTS
HIGHLY INFLUENCED

Leptin signaling and Alzheimer's disease.

  • American journal of neurodegenerative disease
  • 2012
VIEW 5 EXCERPTS
CITES RESULTS & BACKGROUND
HIGHLY INFLUENCED

Leptin regulates AMPA receptor trafficking via PTEN inhibition.

  • The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 2010
VIEW 9 EXCERPTS
CITES RESULTS & BACKGROUND
HIGHLY INFLUENCED

FILTER CITATIONS BY YEAR

2002
2019

CITATION STATISTICS

  • 19 Highly Influenced Citations

  • Averaged 11 Citations per year over the last 3 years

References

Publications referenced by this paper.
SHOWING 1-10 OF 47 REFERENCES

Differential tyrosine phosphorylation of N-methyl-D-aspartate receptor subunits.

  • The Journal of biological chemistry
  • 1995
VIEW 6 EXCERPTS
HIGHLY INFLUENTIAL

Src, N-methyl-D-aspartate (NMDA) receptors, and synaptic plasticity.

  • Biochemical pharmacology
  • 1998
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Leptin stimulates

L Berti, M Kellerer, E Capp, HU Haring
  • 1997
VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL

ERKI/II regulation by the muscarinic acetylcholine receptors in neurons.

  • The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 2000
VIEW 1 EXCERPT

Similar Papers

Loading similar papers…